Born in 1988 in Tehran, Hossein Pishkar began learning traditional Persian music at the age of 4, before studying composition at the University of Tehran. He then studied conducting at the Robert Schumann University in Düsseldorf in 2012, alongside Rüdiger Bohn. 

In 2015, he joined the Dirigenten Forum des Deutschen Musikrates and trained with Marko Letonja, Nicolás Pasquet, Mark Stringer, Johannes Schlaefli and John Carewe. He also worked with Bernard Haitink at the Lucerne Easter Festival in 2016 and with Riccardo Muti at the Italian Opera Academy in 2017. In Iran, he has conducted the Tehran Youth Orchestra and the Tehran School of Music Orchestra. He began playing traditional Persian music at a very young age and has won numerous prizes as a tar player.

Hossein Pishkar's career took on an international dimension in 2017 when he won 1^st prize in the Deutscher Dirigentenpreis at the Kölner Philharmonie with the WDR-Sinfonieorchester. In the same year, he also won the Ernst von Schuch Prize. In 2019, he will be working with François-Xavier Roth, whom he will assist in Philippe Manoury's Lab.Oratorium, with the Gürzenich-Orchester Köln. As second conductor, he also leads the ensemble in performances at the Philharmonie de Paris, the Kölner Philharmonie and the Elbe Philharmonie in Hamburg. Hossein Pishkar has also assisted Sylvain Cambreling with the Junge Deutsche Philharmonie in Berg's Lulu Suite and Rebecca Saunder's violin concerto Still. 

As a guest conductor, Hossein Pishkar has conducted some of the world's leading orchestras, including the Beethoven Orchester Bonn, the Bremer Philharmoniker, the Düsseldorfer Symphoniker, the NDR Radiophilharmonie, the Orchestra Giovanile Luigi Cherubini, the Staatskapelle Halle, the Staatsorchester Stuttgart and the WDR-Sinfonieorchester. He has conducted Bizet's Carmen, Shostakovich's The Nose, Verdi's Aida and Mozart's La Clemenza di Tito at the Royal Danish Opera, Die Zauberflöte at the Stuttgart Staatsoper and Rigoletto at the Ravenna Festival in 2018.

In 2024-2025, Hossein Pishkar will make his debut with the Dortmunder Philharmoniker, the Noord Nederlands Orkest, the Philharmonisches Orchester Kiel, the Wuhan Philharmonic Orchestra, as well as at the Spoleto Festival and the Pazaislis Music Festival in Lithuania. He returns to conduct the Beethoven Orchester Bonn, the Belgrade Philharmonic, the NDR Radiophilharmonie Hannover, the Qatar Philharmonic and the Danish Royal Opera Orchestra.